Art. 52 ChemO indicates when submissions have to be updated:
1. Modifications to the information referred to in Section 5 of this guidance (i.e. the information specified in Art. 49 and 50) must be reported within three months. A submission must always be updated if there is any change in the classification or labelling. If this is not the case, for variations of the concentration of components requiring a submission update, the provisions of Part B Section 4 of Annex VIII to the CLP Regulation can serve as a guide: