Art. 52 ChemO indicates when submissions have to be updated:
1. Modifications to the information referred to in Section 5 of this guidance (i.e. the information specified in Art. 49 and 50) must be reported within three months. An existing submission must always be updated if there is any change in the classification or labelling. If this is not the case, for variations of the concentration of components requiring a submission update, the provisions of Part B Section 4 of Annex VIII to the CLP Regulation can serve as a guide. If an update of the recipe is necessary according to these specifications, a new UFI must also be generated, indicated in the existing report and affixed to the product: